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A slice of vegetable lasagna with visible layers of spinach, mushrooms, and cheese on a white plate, garnished with fresh basil leaves.
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5 from 1 vote

Pesto Lasagna Recipe

This pesto lasagna is a delicious twist on a classic dish. The homemade pesto adds a burst of flavor, and cottage cheese adds a healthy protein kick. With layers of savory mushrooms and gooey cheese, this lasagna is going to be a new favorite!
Prep Time40 minutes
Cook Time1 hour
Total Time1 hour 40 minutes
Course: Pasta
Cuisine: American Fusion
Keyword: pesto lasagna
Servings: 12

Ingredients

Pesto

  • 2 cups packed basil leaves ~40-42 fresh basil leaves
  • 1/2 cup grated parmesan
  • 2 tablespoons fresh lemon juice
  • 2 medium cloves garlic
  • ¼ cup pine nuts
  • ¼ cup olive oil

Other Ingredients

  • 16 oz. lasagna noodles
  • 1.5 tablespoons olive oil
  • 1 small white onion
  • ¾ teaspoon sea salt separated
  • 20 oz. bella mushrooms chopped
  • 5 oz. fresh spinach chopped
  • 1.5 teaspoons Tuscan seasoning or Italian seasoning
  • 22 oz. 2% cottage cheese
  • 2 cups mozzarella cheese separated
  • 2 cups parmesan cheese separated
  • cup fresh basil julienned

Instructions

  • Prepare the homemade pesto. Place all ingredients into a high-speed food processor. Process the ingredients on high for about 1 to 2 minutes. Stop to scrape the sides as needed. Make sure not to over-process, as some grittiness is great for the texture of pesto.
  • If your pesto is too thick, add more olive oil by the teaspoon and pulse until smooth. Set aside.
  • Bring a large pot of salted water to a boil. Cook the lasagna noodles until al dente, about 7 minutes.
    A pot filled with boiling water and lasagna noodles on a stovetop.
  • Strain the noodles and lay them out flat until ready to assemble.
  • Heat the olive oil over medium/high heat. Add onion and season with ¼ teaspoon salt. Saute the onion for 3-4 minutes and then add the mushrooms. Season the mushrooms with another ¼ teaspoon of salt and saute for 7-9 minutes.
  • Add spinach to the mushrooms and cook the spinach down until wilted. Add the Tuscan seasoning to the vegetables and toss. Remove the pan from heat.
    A cast-iron skillet filled with chopped mushrooms on one side and fresh spinach on the other, set on a light-colored surface.
  • Preheat the oven to 350ºF and spray a 9x13-inch pan with olive oil.
  • Blend the cottage cheese in a high-speed blender. Blend until smooth.
  • Add the blended cottage cheese, 1 cup of mozzarella, 1 cup of parmesan cheese, and the remaining salt to a large bowl and mix until combined.
    A glass bowl containing grated cheese and a mixture of white creamy ingredients on a light-colored surface.
  • Assemble the lasagna. Add about ⅓ cup of the cottage cheese sauce to the bottom of the 9x13-inch pan. Spread the sauce over the bottom of the pan—top with 4 lasagna noodles, overlapping just slightly. Next, add ⅓ cup of the cottage cheese mixture to the top of the noodles and gently spread the mixture with a spatula. Spread ½ cup of the mushroom mixture over the top of the cottage cheese sauce. Repeat this process until the cottage cheese sauce and mushroom mixture have been used.
    A white baking dish containing an uncooked layered green and white lasagna against a textured light gray surface.
  • Top the whole lasagna with the remaining mozzarella and parmesan cheese and cover.
    A rectangular white baking dish filled with unbaked lasagna, topped with a layer of shredded cheese, placed on a light-colored surface.
  • Bake the lasagna for 20 minutes at 350ºF, uncover, and bake for an additional 20-30 minutes or until the cheese is golden brown.
    A baked lasagna in a white rectangular dish, topped with melted cheese and garnished with fresh basil leaves. A wooden pepper grinder and fresh basil are visible in the background.
  • Remove the lasagna from the oven and let it rest for 15 minutes before serving. Top with fresh basil and enjoy.
    A slice of vegetable lasagna on a plate, featuring layers of pasta, mushrooms, spinach, ricotta, and topped with a basil leaf.

Video

Notes

  • We do not recommend using store-bought pesto. You end up with a very oily lasagna. Use at your own risk.
  • Option to replace the blended cottage cheese with ricotta cheese.
  • The main difference between Tuscan seasoning and Italian seasoning is that Tuscan seasoning has added red pepper flakes, dried bell peppers, and minced garlic.

Nutrition

Calories: 424kcal | Carbohydrates: 36g | Protein: 24g | Fat: 21g | Fiber: 2g | Sugar: 4g